In 1996, based in US new technologies to improve the detection of cervical cancer disease in a premalignant state are being developed. These technologies is call Thin-layer pap Preparation (Thinprep) Pap Test is the most comprehensive and FDA-approved. These system was using filtration technology. (Cervical cells are collected from the cervix and rinse into liquid-based formulation solution. Once the sample arrives at the laboratory, the cervical cells are uniformly transferred to a filter. This technology eliminates air-drying artifacts and other factors that interfere with interpretation, thereby improving the detectability of abnormalities. Although newer technologies are aimed at reducing the false-negative rate of the Pap smear, but these Thinprep system has its own limitations in terms of technical problems, ease of operation and big factor in asean country cost effectiveness for the test.)
In 2009, latest the new generation Liquid-based pap preparation system, Pathology screening pap Test (PathTezt®) is an automated computer-controlled device designed to prepare standardized thin-layer cytological pap preparations using a filtration system, these system special is improvement the old method system problem liquid-based cytology (patchy cell lost and smears cell lost that show “halo”). PathTezt® processor improve for the old method filtration technology and reduce the cost effectiveness for the cervical cancer screening test.
Even if your lab already has an automated mono-layer cytology system, Pathtezt™ is an excellent backup method!
-Thin-layer pap preparation
-Controlling cellular density
-Distributing cells uniformly
-Reducing obscuring elements(blood, mucus and inflammatory cells)
-Eliminating air-drying artifacts
-Maintaining cell architecture
-Improving cellular morphology
-Enhancing nuclear detail
-Retaining important background clues